Voritrol

How Voritrol works

Voritrol is used to treat fungal infections caused by a variety of organisms but including Aspergillus spp. and Candida spp. Voritrol is a triazole antifungal exhibiting fungistatic activity against fungal pathogens. Like other triazoles, voriconazole binds to 14-alpha sterol demethylase, also known as CYP51, and inhibits the demethylation of lanosterol as part of the ergosterol synthesis pathway in yeast and other fungi. The lack of sufficient ergosterol disrupts fungal cell membrane function and limits fungal cell growth. With fungal growth limited, the host's immune system is able to clear the invading organism.

Side Effects

Anaphylactoid reactions (e.g. flushing, fever, sweating, tachycardia, chest tightness, dyspnoea, faintness, nausea, pruritus, rash). Photosensitivity reactions, skeletal effects e.g. fluorosis, periortitis (in long-term therapy), visual disturbances (e.g. abnormal or blurred vision, color vision change, photophobia), GI effects (nausea, vomiting, diarrhoea, abdominal pain), fever, rash, chills, headache, abnormal LFT result, tachycardia, hallucinations.

Food Interaction

Take separate from meals. Take voriconazole at least one hour before or after eating for optimal absorption.